NEW YORK: US scientists laga ekta team khan etu te Indian-origin researcher logote milikena ekta human genes laga set paishe kuntu para SARS-CoV-2 infection logote ladai kuri ase etu virus para covid 19 pai.
Sumit K. Chanda, professor and director of the Immunity and Pathogenesis Programme Sanford Burnham Prebys Medical Discovery Institute, para kuwa hisaab te scientist khan duita nutun insights paishe kinika etu virus para human cells te dikdaar dishe chuwas pichede.
Chanda para ekta paper journal Molecular Cell te koikena janaidiya thakishe ki ami khan para ekta Achille’s Heel toh etia tak bisari ase etu para ami khan ekta optimal antivirals khan bisaribole paribole nimete.”’
Etu ki genes ase etu viral infection rukhabole nimete researchers khan ke modot kuribo factors khan bujibole nimete kuntu para beemar te dukh dishe aro lagi thaka therapeutic options khan ase.
etu genes khan sawal toh interfernos uporte ase body laga frontline virus fighters khan ase.etu pandemic toh shuru huwa logote clinicians khan para ekta komjor interferon response paishe SARS-CoV-2 infection nimete etu te covid 19 laga bishi biya wala cases khan thakishe.
Etu janaa para chanda aro tai laga collaborators khan human genes khan bisaribole olaishe etu toh interfernos para interferon-stimulated genes (ISGs), para dikdaasr paishe etu para SARS-CoV-2 infection komti kurishe.
Chanda para koikena janaishe “ami khan paishe ki 65 ISGs controlled SARS-CoV-2 infection etu te virus ability cells te ghussibole bondh kurishe etu te RNA laga manufacturers khan the virus’s lifeblood, nimete aro genes laga clusters para virus khan jamaa kurishe.
Aro toh janibole thaka toh etu te knba ISGs khan control dikhaishe najaana viruses nimete etu te seasonal flu, West Nile and HIV kuntu para AIDS ola toh thakishe.”
Etu team para aata ISGS paishe kuntu para SARS-CoV-1 and CoV-2 replication olaishe subcellular compartment te etu bi protein packaging nimete etu para dikhaishe etu vulnerable site toh clear viral infection para dikdaar pabo.
Laura Martin-Sanch senior postdoctoral associate Chanda lab te koikena janaishe”etu toh ekta khaas khobor ase hoilebi ami khan etia tak hikible lageh etu virus laga biology nimete aro chan bin kuribole lageh judi genetic variability etu ISGs bithor te covid19 severity logote mila toh.”
Dusra step toh researchers khan para SARS-CoV-2 variants laga biology te sabole aser etu toh olai thakishe aro vaccine efficacy te dhamki dishe.
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